Disulfide Linkage of Growth Hormone (GH) Receptors (GHR) Reflects GH-induced GHR Dimerization
نویسندگان
چکیده
منابع مشابه
Disulfide linkage of growth hormone (GH) receptors (GHR) reflects GH-induced GHR dimerization. Association of JAK2 with the GHR is enhanced by receptor dimerization.
The growth hormone (GH) receptor (GHR) binds GH in its extracellular domain and transduces activating signals via its cytoplasmic domain. Both GH-induced GHR dimerization and JAK2 tyrosine kinase activation are critical in initiation of GH signaling. We previously described a rapid GH-induced disulfide linkage of GHRs in human IM-9 cells. In this study, three GH-induced phenomena (GHR dimerizat...
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Department of Biological Sciences, North Dakota State University, Fargo, ND 58108, USA 7 8 9 10 11 12 13 14 15 Running Head: Growth hormone signaling 16 17 18 19 20 21 22 23 Address correspondence and send proofs to: 24 Dr. Mark A. Sheridan 25 Department of Biological Sciences 26 North Dakota State University 27 P.O. Box 6050, Dept 2715 28 Fargo, ND 58108-6050 29 Tel: 1-701-231-8110; Fax: 1-701...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1999
ISSN: 0021-9258
DOI: 10.1074/jbc.274.46.33072